Leucovorin (folinic acid) is emerging as a compelling area of research for addressing specific core symptoms of Autism Spectrum Disorder (ASD), particularly for children experiencing language delays or verbal communication barriers. Unlike standard folic acid, leucovorin is a highly bioactive form of vitamin B9 that can bypass metabolic "roadblocks," such as Cerebral Folate Deficiency (CFD) or the presence of folate receptor autoantibodies. By ensuring the brain receives the folate it needs for neurotransmitter synthesis and nerve development, this treatment has shown measurable promise in improving expressive language and social interaction in clinical trials.
