>>53573
"Alpha synuclein, having no single, well-defined tertiary structure, is an intrinsically disordered protein ... which, under certain pathological conditions, can misfold in a way that exposes its core hydrophobic residues to the intracellular milieu, thus providing the opportunity for hydrophobic interactions to occur with a similar, equally exposed protein.[80] This could lead to self assembly and subsequent aggregation into large, insoluble fibrils known as amyloids."