Reader 04/08/2020 (Wed) 19:28:02 Id: f82cf1 No.15781 del
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"In molecular biology, insertional mutagenesis is the creation of mutations of DNA by addition of one or more base pairs. Such insertional mutations can occur naturally, mediated by viruses or transposons, or can be artificially created for research purposes in the lab.
>Results: Uncanny similarity of novel inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
>We then translated the aligned genome and found that these inserts are present in all Wuhan 2019-nCoV viruses except the 2019-nCoV virus of Bat as a host
>Intrigued by the 4 highly conserved inserts unique to 2019-nCoV we wanted to understand their origin
>Surprisingly, each of the four inserts aligned with short segments of the Human immunodeficiency Virus-1 (HIV-1) proteins.
>However, it is unlikely that all 4 inserts in the 2019-nCoV spike glycoprotein fortuitously match with 2 key structural proteins of an unrelated virus (HIV-1).
>To our surprise, these sequence insertions were not only absent in S protein of SARS but were also not observed in any other member of the Coronaviridae family
>This is startling as it is quite unlikely for a virus to have acquired such unique insertions naturally in a short duration of time.
>The genome sequence from the recent 28 clinical isolates showed that the sequence coding for these insertions are conserved amongst all these isolates.
>This indicates that these insertions have been preferably acquired by the 2019-nCoV, providing it with additional survival and infectivity advantage.
>Since surface proteins are responsible for host tropism, changes in these proteins imply a change in host specificity of the virus.
>According to reports from China, there has been a gain of host specificity in case 2019-nCoV as the virus was originally known to infect animals and not humans but after the mutations, it has gained tropism to humans as well.
>Further, this structural change might have also increased the range of host cells that 2019-nCoV can infect.