Reader 04/19/2020 (Sun) 14:58:17 Id: 06ea73 No.15810 del
https://www.medpagetoday.com/infectiousdisease/covid19/86029
Guillain-Barre Linked to COVID-19 in Italy
— Five patients developed GBS following COVID-19 infection

by Judy George, Senior Staff Writer, MedPage Today April 17, 2020
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GBS is an acquired demyelinating polyneuropathy with an axonal variant, often beginning in the lower extremities and ascending over time, with loss of reflexes. Some cases start a few days or weeks after respiratory or gastrointestinal viral infection. Treatment often is intravenous immunoglobulin (IVIG) or plasmapheresis. Diagnosis may include electromyography and nerve conduction studies; CSF may contain elevated protein but minimal or no cells.

In the Italian cases, GBS symptoms began 5-10 days after the first COVID-19 symptoms. Four patients had onset with lower-limb weakness and paresthesias; one had facial diplegia, then ataxia and paresthesia. Four of the five developed generalized flaccid tetraplegia, and three patients required mechanical ventilation.