I think I'm going to go with this configuration:

Hyperbola/GNU/linux-libre-lts/OpenRC/ base + xorg-server + Guix for packages

I think that's as GNU as it gets right now.

https://www.gnu.org/software/guix/download/

https://www.gnu.org/software/guix/manual/en/html_node/Binary-Installation.html

## The only thing with the manual is that you need to download the current binaries and signatures and
## apply the steps to those files. You may have to download the signing key manually if gpg fails.

That way I can boot into my encrypted LVM, with the linux-libre-lts kernel, and then pull new packages from the guix repository. I've got the guix-daemon installed on my experimental partition this way, and installed zsh from the guix repository to test it (seems to be working). I may have to change the partition sizes to make more room for the guix packages in /var. Most of this goes into /var/ and /gnu/ , so I might have to make /var a slightly larger partition to accommodate.

If someone could make a portable version of emerge from Gentoo and have it operate like guix in it's own profile space then that would be the final frontier. Then you could set priority from where you launch your binaries in the $PATH variable or someone could dream up a more advanced scheme setting priority to emerge compiled binaries over guix over base from pacman or the other way around.