Normally I wait to finish shows before I do a breakdown, but since hungryanon was salty about it, I'll make an early assessment.

Pluribus was written 10 years ago, around the time Vince was releasing Breaking Bad. At the time Vince experienced his first dealing with the collective of the internet, and two particular cases.
One, guilt over people who sided with Walter and enjoyed it as a dark escapist fantasy. Despite Vince himself using the show as his own dark escapist fantasy, he felt responsible for possibly causing harm in society.
Two, the Skylar issue and the ensuing social network debates.

The show deals with the protagonist's emotions and words having power over the pluribus and causing massive deaths, but at the same time they are not individuals so the deaths shouldn't even matter.
As other Vince's works its primarily a self-serving fantasy, but its built on the sense with the internet alone we already morphed into a bit of a noosphere, and that certain people have more power to influence it than others and that comes with a moral price.

Its more questioning how do we deal with an emerging collective, than defending or criticizing the creation of said collective.