All the usual things are there, stats, and skills, feats and char creation, and weapons, and armor, and decisions to make. There is some philosophical and political undertone, the game tracks the character's disposition in these as well.
They made a stealth aspect to the game, offering alternatives to solve some situations differently. I think more often than not the player can chose to be diplomatic, using reason or fast talk; or go ahead gung ho and just kill everyone to reach his goals. Some situations - like battling with monsters, there is little choice.
The companions has some background stories, they only join if one resolves certain quests in a way that allow them to join. Sometimes picking a side is needed to chose between two followers (I read about this, haven't had to make the decision yet). They have opinions on things sometimes contrary to each other, and their performance is affected by how much they like your choices and fit in the group.
On leveling up the player gets to pick a feat. Skills are leveling up automatically, by use. If you open locks, your lockpick will grow. If you get hit in combat, your armor skill will grow.
The attributes which they call stats, are fixed at character creation, some of them can be raised by cyberware implants - which can be upgraded further to buff derivative stats.
The combat seems a bit complicated compared to Fallout. Several kind of attacks are offered with each weapon, can aim bodyparts, quick attack, normal attack, long burst, short burst, there is "reaction" attacks, grazes, penetration level, and whatnot.
Head, arms, torso, legs are needed to be protected by armor. Against bullets, melee weapons, and energy ones. But they eyes also need protection, and have to be resistant against poison and psionic attacks.
I think this pretty much sums it up.